<big id="djzjn"></big>

          <big id="djzjn"><meter id="djzjn"></meter></big>

          <progress id="djzjn"><thead id="djzjn"></thead></progress>

          <noframes id="djzjn"><thead id="djzjn"></thead>

            <sub id="djzjn"><font id="djzjn"><b id="djzjn"></b></font></sub>

                <big id="djzjn"><meter id="djzjn"></meter></big>

                  <sub id="djzjn"><font id="djzjn"><cite id="djzjn"></cite></font></sub>
                  立即咨詢
                  您當前的位置:職稱驛站 > 論文 > 醫學論文 > 藥學論文職稱驛站24小時論文發表咨詢熱線:400-680-0558

                  醫藥職稱評審論文銅綠假單胞菌耐藥分析管理戰略方針

                  職稱驛站所屬分類:藥學論文發布時間:2016-11-11 14:16:20瀏覽:1

                  現在對銅綠假單胞菌有哪些新的介紹和應用,同時對于這些耐藥性的研究調查有什么方式,文章對這些方面做了新的研究,本文選自:《醫藥世界》,《醫藥世界》雜志是中華人民共和國衛生部主管、中華預防醫學會第一主辦、北京東方迅達醫藥信息咨詢中心第二主辦的醫藥科普期刊,創辦于1999年,由醫藥世界雜志社有限公司編輯、出版、發行,是我國醫藥衛生類科普期刊中具有較大影響力的品牌期刊。雜志秉持"傳播醫藥科學,倡導健康生活"的辦刊宗旨,為社會高端大眾提供醫藥科學普及的傳媒服務。

                     現在對銅綠假單胞菌有哪些新的介紹和應用,同時對于這些耐藥性的研究調查有什么方式,文章對這些方面做了新的研究,本文選自:《醫藥世界》,《醫藥世界》雜志是中華人民共和國衛生部主管、中華預防醫學會第一主辦、北京東方迅達醫藥信息咨詢中心第二主辦的醫藥科普期刊,創辦于1999年,由醫藥世界雜志社有限公司編輯、出版、發行,是我國醫藥衛生類科普期刊中具有較大影響力的品牌期刊。雜志秉持"傳播醫藥科學,倡導健康生活"的辦刊宗旨,為社會高端大眾提供醫藥科學普及的傳媒服務。

                  醫藥世界雜志投稿論文

                    摘要:銅綠假單胞菌的耐藥機制較復雜,有β-內酰胺酶、青霉素結合蛋白酶(PBPS)的結構和功能改變,細胞外膜主動外排系統的表達、外膜蛋白改變致通透性降低等,帶有耐藥質粒的銅綠假單胞菌的大量存在是造成銅綠假單胞耐藥菌株逐年增高的重要原因。

                    關鍵詞:銅綠假單胞菌,藥性分析,醫藥論文

                    1 資料與方法

                    1.1 標本來源 2001年1月~2003年12月從臨床各科標本中分離的銅綠假單胞菌107株。

                    1.2 儀器及試劑 MicroScan WalkAway-40型全自動微生物鑒定/藥敏測試儀及儀器配套使用的NC21鑒定/藥敏復合測試板為美國DADE公司出品;傳統生化微量管為杭州微生物試劑廠生產。

                    1.3 質量控制 標準菌株為銅綠假單胞菌ATCC2783、大腸埃希菌ATCC25922,由江西省臨床檢驗中心提供。

                    1.4 方法

                    1.4.1 分離菌株 嚴格按《全國臨床檢驗操作規程》對送檢標本進行分離培養,選取在哥倫比亞血瓊脂培養基上生長良好的革蘭陰性桿菌,測氧化酶試驗陽性者,做菌種鑒定。

                    1.4.2 菌種鑒定/藥敏測試 按MicroScan Walkway-40操作手冊對選取的菌落上機進行菌種鑒定和藥物敏感性測定,對鑒定值偏低的菌株補充傳統生化試驗,以確認銅綠假單胞菌,并再次上機做藥敏測試。藥物敏感性由機內自動分析系統根據美國國家臨床實驗室標準委員會(NCCLS)制定的MIC折點確定耐藥與否。

                    1.4.3 分析方法 107株銅綠假單胞菌耐藥性分析采用世界衛生組織細菌耐藥性監測中心推薦的WHONET5軟件進行分析。

                    2 結果

                    2.1 107株銅綠假單胞菌在各種臨床標本中的分布率 從2001~2003年從各種臨床送檢標本中分離銅綠假單胞菌107株,其中痰液77株(71.2%)、咽拭子14株(13.1%)、分泌物9株(8.3%)。107株銅綠假單胞菌在各種臨床標本中的分布,見表1。

                    2.2 107株銅綠假單胞菌對12種抗菌藥物體外敏感試驗結果 顯示12種抗菌藥物活性較好的是亞胺培南、阿米卡星、哌拉西林/他唑巴坦,耐藥率為0.9%、5.6%、6.5%;耐藥率較高的是頭孢曲松鈉63.6%、頭孢噻肟鈉38.3%,氨曲南25.2%。見表2。

                    2.3 2001~2003年銅綠假單胞菌對12種抗生素的耐藥率比較 顯示三代頭孢菌素中頭孢他啶、頭孢曲松鈉、頭孢噻肟鈉、氨曲南明顯呈逐年增高,由2001年的14.8%,33.3%,48.1%,22.2%到2003年增至24.4%,44.4%,68.9%,28.9%;β-內酰胺類藥物哌拉西林耐藥率有下降趨勢,由22.2%降至15.6%。見表3。

                    3 討論

                    銅綠假單胞菌是臨床最常見的病原菌之一。近幾年來國內外報道呼吸道感染的病原菌主要是革蘭陰性桿菌,其中又以銅綠假單胞菌最為多見,耐藥的銅綠假單胞菌感染常導致嚴重后果,是臨床治療中的一個難點。我院2001年1月~2003年12月分離的107例銅綠假單胞菌在各種臨床送檢標本中以呼吸道標本占首位(痰液71.2%,咽拭子13.9%),提示本院銅綠假單胞菌主要是以呼吸道感染為主,與國內有關文獻報道一致[1,2]。

                    表2顯示107株銅綠假單胞菌對抗菌藥物活性最好的依次是碳青霉烯類-亞胺培南、氨基糖苷類-阿米卡星、β-內酰胺酶抑制劑的復合藥物-哌拉西林/他唑巴坦。亞胺培南是一種非典型的β-內酰胺類抗菌藥物,其對銅綠假單胞菌的活性,主要是通過特殊的孔蛋白通道OprD的擴散而實現的,這就意味著一旦孔蛋白通道消失,則銅綠假單胞菌對亞胺培南就會產生耐藥性。事實上,國家細菌耐藥監測研究組(BRSSG)2001年、2002年的統計數據表明國內多家醫院臨床分離的銅綠假單胞菌對亞胺培南的耐藥率已分別達13.1%~19.1%[3,4];MYSTIC細菌耐藥監測組在2002年第42屆ICAAC會上報告美國對銅綠假單胞菌(1999~2002)監測結果時,列出銅綠假單胞菌對亞胺培南,頭孢吡肟的敏感率均為86.9%,頭孢他啶敏感率為83.2%[5],我院分離的銅綠假單胞菌對亞胺培南的耐藥率僅為0.9%,明顯低于上述報告,可能與臨床較嚴格的控制使用該藥有關。阿米卡星、妥布霉素的耐藥率為5.6%,10.3%,是因為氨基糖苷類藥物雖然有抗銅綠假單胞菌的活性,但其腎毒性較大,主要用在聯合治療時使用,臨床較少單獨使用。三代頭孢菌素-頭孢吡肟,氟喹諾酮類-環丙沙星均以13.1%的耐藥率低于其他三代頭孢菌素,表現出較好的抗菌活性,頭孢吡肟的耐藥率與MYSTIC的報告基本相同。

                    值得注意的是β-內酰胺酶抑制劑的復合藥物可抑制細菌產生質粒介導的廣譜β-內酰胺酶,使因產酶而致耐藥的菌株轉為敏感,其抗菌作用顯著優于單藥成分,如哌拉西林/他唑巴坦使銅綠假單胞菌對哌拉西林的耐藥率從17.8%降至6.5%。同時表3顯示哌拉西林耐藥率有下降趨勢,2001~2003年分別為22.2%,17.1%,15.6%,3年下降6.6%,原因有待研究。

                    在12種抗菌藥物中三代頭孢菌素的耐藥率,中介率呈逐年增長,引起我們的關注。其中107株銅綠假單胞菌對頭孢曲松鈉耐藥率63.6%,頭孢噻肟鈉耐藥率雖然為38.3%,但其中介率高達48.6%,如表3所示,銅綠假單胞菌對頭孢噻肟鈉的耐藥率從2001年33.3%升至2003年的44.4%,同期對頭孢曲松鈉的耐藥率從48.1%升至68.9%,升幅達11.1%,20.8%,高于國家細菌耐藥監測研究組(BRSSG)2001年、2002年的統計結果,這不僅與細菌本身的生物學特征有關,還可能與三代頭孢菌素在我院臨床的廣泛應用密切相關,有必要加強對銅綠假單胞菌耐藥率有計劃的連續監測。

                    雖然根據實驗室藥敏試驗結果用藥與臨床實際感染控制情況有一定差異,但比經驗用藥針對性強效果好[6]。為提高療效、減少藥物不良反應、減少耐藥菌株的產生、延長抗生素使用壽命和合理使用抗生素,臨床醫生應按規范積極送檢感染標本。同時,加強藥敏監測可以彌補由于細菌報告不能及時獲得的缺陷,在長期的耐藥監測數據中總結出本院及院內各病區主要致病菌的耐藥規律,制定合理的治療方案,對降低細菌耐藥率、有效控制醫院感染具有重要意義。

                  《醫藥職稱評審論文銅綠假單胞菌耐藥分析管理戰略方針》
                  • 課教專著
                  • 1
                  • 2
                  • 3
                  聚福彩票 WWW.523146.COM | 777848.com | WWW.195977.COM | www.bet91483.com | lh66z.com | www.594883.com | www.sygj2.com | www.85857v.com | 2682.com | www.167090.com | WWW.195162.COM | www.38775bb.com | 28365.com | 276666.com | WWW.862053.COM | www.18955.bet | 4255fff.com | 06982.com | WWW.899566.COM | www.42456622.com | 033p.net | 36401144.com | www.277739.com | WWW.709343.COM | www.8905e.com | hga025.com | 2546p.com | WWW.519755.COM | www.hct5.com | www.588870.com | y68bb.com | 2544b1.com | WWW.741448.COM | www.3478j.cc | www.97828c.vip | 5443uu.com | 00888448.com | www.250209.com | WWW.278948.COM | www.js7581.com | www.c668.cc | v444000.com | 81669.com | WWW.792731.COM | WWW.668450.COM | www.30350z.com | 0245q.com | 1168i.com | www.136503.com | WWW.98488.COM | www.07163p.com | www.1429c1.com | 33318t.com | L8520.com | www.86267a.com | WWW.749667.COM | www.ban02.com | www.63606v.com | jsjlb7.com | dz316.com | 22558332.com | www.510830.com | WWW.241177.COM | www.022f.cc | www.vnsr398.com | 3245999.com | 4255www.com | xpjgo8.com | www.86267v.com | WWW.35242.COM | WWW.585409.COM | www.50989k.com | www.245885.com | 97618o.com | 53358.com | 59522w.com | 78111155.com | www.500103.com | WWW.110470.COM | WWW.495898.COM | www.77801d.com | www.00778n.com | www.670665.com | WWW.345943.COM | WWW.5940.COM | www.23579b.com | www.69488.com | www.ggy.99233y.com | 704.com | 4289h.com | 1654vv.com | 33432p.com | www.349177.com | WWW.64606.COM | WWW.84339.COM | WWW.156463.COM | www.96386j.com | www.1022777.com | www.5966iii.com | t58955.com | 2172226.com | 5350.com | 2381aaa.com | zz2205.com | www.191855.com | www.843633.com | WWW.393089.COM | WWW.330620.COM | www.1368g.cc | www.00840c.com | www.55545x.com | www.3846f.com | www.0169c.com | www.l948l.com | 444p1.cc | 923250.com | WWW.4296.COM | WWW.226835.COM | WWW.370367.COM | WWW.555099.COM | WWW.764634.COM | www.ssme8.com | www.3479f.com | www.11260.cc | www.0014f.com | www.50054r.com | www.8582qq.com | www.pj99e.com | www.087r.com | www.116874.com | www.40288b.com | www.6880oo.com | www.5099gg.com | www.9928e.com | www.55526u.com | 55155d.com | d3144.com | 500000315.com | 13822.com | bet28c.com | 33318n.com | v2299.com | 55442007.com | 08530007.com | zhcp63.com | 2381cc.com | 3049d.com | 6868cc.cc | 1624xx.com | 38822211.com | www.7agcpw.com | www.35252k.com | www.85857l.com | www.1064b.com | www.hccp998.com | www.0066xpj.net | www.173151.com | www.43389.com | www.742388.com | www.087o.com | www.566493.com | www.77801f.com | www.3890s.com | www.hr3888.com | WWW.176285.COM | WWW.237488.COM | WWW.140029.COM | WWW.452225.COM | WWW.872304.COM | www.755903.com | www.393477.com | 007300.com | 6118a.com | 496dd.com | 66458h.com | bogou2222.com | 4060vv.com | 8381c.com | 1407o.com | www.00618e.com | www.614586.com | www.096968.com | www.66653j.com | www.66ffy.com | WWW.272539.COM | WWW.673756.COM | WWW.611435.COM | www.544559.com | 382333.com | 8905n.com | 80878m.com | 84497722.com | www.8499b.com | www.7406.Com | WWW.256947.COM | WWW.670267.COM | WWW.118666.COM | www.686783.com | www.7478.com | hg0088.tech | y73888.com | 8827mm.com | www.35252d.com | www.bet73k.com | www.cp500.pw | WWW.633529.COM | www.505507.com | 2418t.com | 3y123.com | pj09922.com | www.224.com | www.xpj3123.com | www.61655t.com | WWW.416733.COM | WWW.817442.COM | www.65707i.com | rr8159.cc | 2222k05.com | 5443v.com | www.vnsr938.com | www.33588y.com | WWW.361164.COM | www.976281.com | www.0967678.com | 66300vip39.com | a98c.com | www.99113q.com | www.35898.COM | WWW.907166.COM | WWW.368189.COM | www.36788e.com | xpj215.com | 5525.us | www.xpj11885.com | www.hf6680.com | WWW.155542.COM | www.191079.com | 65005v.com | 33pp8332.com | www.5446j.com | www.c1636.com | WWW.399946.COM | 00221.com | 0652l.com | www.7793e.com | www.919654.com | WWW.902969.COM | www.983888a.com | bet444000.com | 9068m.com | www.8864tt.com | www.35918s.com | WWW.393398.COM | 1788333.com | bmw8077.com | www.jjjj22222.com?5130.cc | www.w98478.com | WWW.640014.COM | www.599684.com | 75991b.com | mgm3242q.com | www.954321e.com | WWW.887144.COM | www.133902.com | js14.com | www.4136l.com | www.hycb8.com | www.900845.com | 5144l.com | 518cp55.com | www.4331h.com | WWW.179325.COM | www.71233o.com | uedhot8844.com | www.26123aa.com | www.le96.com | www.529799.com | 5647y.com | www.dggcp.com | www.5086x.com | WWW.164433.COM | 3189xx.com | 79964b.com | www.50732y.com | WWW.678926.COM | 7552.com | 4639955.com | www.1368t.cc | www.663738.com | 55967e.com | www.99393.com | www.fcff4.com | www.599643.com | 15a37.net | www.0099xpj.net | WWW.688264.COM | www.198109.com | 3467j.am | www.d63568.com | WWW.869889.COM | 56988d.com | 22556r.com | www.8499n.com | www.769588.com | p89.cc | www.4058m.com | WWW.557030.COM | www.t2005.net | 3685m.com | www.41518j.com | www.791571.com | 99909k.com | www.y2894.com | WWW.200887.COM | www.5854y.cc | www.371477.com | 9506n.com | www.13434d.com | WWW.765877.COM | 6645365.com | www.704909.com | WWW.632448.COM | 22449193.com | www.4694q.com | WWW.56308.COM | feicai0423.com | 1775mm.com | WWW.276156.COM | www.518555.com | 4997q.com | www.073wy.com | 020808.com | zhcp19.com | WWW.732921.COM | 566846a.com | 131a.net | WWW.782323.COM | b762.xyz | www.551c93.com | WWW.205188.COM | 3089e.com | www.bet91487.com | WWW.79108.COM | 12742h.com | www.5886nn.com | WWW.836234.COM | 3304tt.com | www.8998977.com | www.799481.com | 4018e.com | www.15256.cc | hj5068.com:8888 | www.p948p.com | WWW.366879.COM | 9464002.com | www.6687l.com | WWW.180700.COM | 4461.com | www.12455n.com | xg118.com | www.s948s.com | WWW.298039.COM | 444144.com | www.68365k.com | www.911059.com | 80368b.com | www.hf5881.com | 7172.us | www.6880yy.com | WWW.637331.COM | 566777.com | www.2875o.com | 1288jj.com | www.0169a.com | WWW.204599.COM | 4426.com | www.9jjc.com | 3950f.com | www.256095.com | www.548116.com | 33115g.com | WWW.417163.COM | 131tt.net | www.87668c.com | www.449123.com | www.5446aa.com | WWW.362075.COM | 52599.com | WWW.767853.COM | 9949y.com | www.pujing65.com | www.800.as | www.673888z.com | WWW.52524.COM | 2643v.com | WWW.205776.COM | 4488c.com | www.66qxc.com | by305.com | www.x888678.com | www.78949e.com | www.g32939.com | WWW.447361.COM | 3189jj.com | 33115tt.com | WWW.530737.COM | 3834505.com | WWW.787678.COM | 9649f.com | www.1368o.cc | 3844yy.com | www.66653t.com | k47479.com | www.bmw8003.com | www.86229.com | www.4521e.com | www.246841.com | www.89599i.com | www.687044.com | www.r948r.com | WWW.52768.COM | 8159ll.cc | WWW.254765.COM | 6830p.com | WWW.807949.COM | 0068.cc | WWW.864185.COM | 7742o.com | WWW.166369.COM | z86811.com | WWW.807025.COM | 2142233.com | WWW.26296.COM | 00773uu.com | WWW.131944.COM | xx1101.com | WWW.834609.COM | zhcpff.com | WWW.887765.COM | ff555w.com | WWW.705906.COM | www.61msxfpt2.com | www.887575.com | www.cs66.com | www.258768.com | www.c83377.com | www.87833.com | www.3691m.com | 188qq33.com | www.80065z.com | 2096s.com | www.c9223.com | dd8662.com | WWW.518909.COM | v997b.com | WWW.25727.COM | 914909.com | www.838669.com | www.10999p.com | www.01903.com | www.hg0295.com | 53262l.com | www.666xm.cc | rb431.com | WWW.271109.COM | jinguan3355.com | www.916370.com | www.bwinyz11.com | www-4907.com | www.52303h.com | js999js.com | WWW.271729.COM | 64111v.com | www.910155.com | www.c80288.com | 8988i.com | www.21202z.com | 3066aaa.com | WWW.686035.COM | 668866.com | www.298980.com | www.yh08118.com | 16290077.com | WWW.214493.COM | nn2205.com | www.524947.com | www.57777.am | 1654zz.com | WWW.99503.COM | 9964u.com | www.277320.com | www.038839.com | 9679o.com | WWW.828222.COM | www.77731r.com | 38888p.com | www.53539.cc | 1466o.com | WWW.573076.COM | www.60886f.com | 4123oo.com | WWW.323482.COM | mmm8827.com | www.135842.com | www.60123c.com | gg40033.com | WWW.720017.COM | www.xj6002.com | 409898.com | WWW.491403.COM | 1705z.com | www.901690.com | www.073wy.com | 00226132.com | www.278965.com | www.77114d.com | 77606r.com | www.827737.com | www.392518.com | 8015x.com | WWW.79198.COM | www.93919f.com | hh01234.com | WWW.840181.COM | www.733485.com | 4022rr.com | WWW.267367.COM | www.60886.com | 7240w.com | WWW.780904.COM | www.44118u.com | p61653.com | WWW.893477.COM | www.68365q.com | 4775522.com | WWW.768468.COM | www.hd8676.com | 5856kk.com | www.610560.com | www.52303f.com | 73055e.com | www.81520u.com | www.hx1116.com | 650pj.com | hkmh33.com | WWW.339559.COM | www.9570118.com | 1413.com | WWW.6535.COM | www.22062c.com | h08199.com | www.26878a.com | WWW.485905.COM | www.77731u.com | 5804s.com | WWW.780767.COM | www.h36588.com | 04666t.com | www.324377.com | www.flff0.com | www.97cp123.com | 20040.com | WWW.44093.COM | www.6678566.com | 33nn8332.com | www.740933.com | WWW.198283.COM | www.9931331.com | 0485n.com | www.569799.com | www.qucw5.com | www.a456x.com | 99699q.com | WWW.12010.COM | www.50788g.com | 2643x.com | 61789t.com | WWW.292559.COM | www.71399l.com | 2247f.com | 80892ii.com | WWW.174546.COM | www.54400p.com | ca7099.com | vns8e.com | WWW.555876.COM | www.5095z.com | www.27363v.com | 041122r.com | www.562500.com | WWW.900354.COM | www.1851116.com | 38365b.com | 389.cc | WWW.825830.COM | 61329966.com | www.785779.com | WWW.549709.COM | www.4196b.com | 3807mm.com | d32365.com | WWW.510649.COM | www.65707l.com | www.c44ll.com | 88535s.com | www.031069.com | WWW.490805.COM | www.500558.com | 68963999.com | hb1432.com | www.401273.com | WWW.147654.COM | www.x77789.com | 44ww8331.com | 2018nsb.com | www.217030.com | WWW.215214.COM | www.ra8855.com | www.n948n.com | 30174433.com | 005536.com | WWW.245975.COM | www.yi328.com | www.9908598.com | 9958955.com | 3656aa.com | www.376477.com | WWW.7758.COM | www.60108s.com | www.7334a.com | v3405.com | 3225h.com | www.514033.com | WWW.846927.COM | www.76520w.com | www.47709.net | 455yh.com | 8381kk.com | www.229958.com | WWW.678547.COM | www.5086s.com | www.06820c.com | 009900i.com | 全讯网.com | kj377.com | WWW.458909.COM | WWW.700440.COM | www.00665e.com | www.85xpj.com | 80368qq.com | 1705l.com | 703111.com | WWW.689232.COM | WWW.153996.COM | www.78949y.com | www.03a88.com | 500000757.com | zjgcfc.com | 63305a.com | www.235399.com | WWW.408765.COM | WWW.337448.COM | www.0270z.com | www.7893w38.com | 5168555.cc | uuu4165.com | 66287r.com | www.7749.com | www.760557.com | WWW.19412.COM | WWW.358780.COM | www.sx1822.com | www.45598g.com | 50024444.com | 56822.com | 3846fff.com | 33567e.com | www.038909.com | WWW.366348.COM | WWW.147322.COM | WWW.302941.COM | www.86267m.com | www.jsdc9777.com | www.55545p.com | 6220ee.com | hg2886.com | 8449bb.com | 11998332.com | www.35888358.com | www.342677.com | WWW.313889.COM | WWW.675007.COM | WWW.21208.COM | www.3416x.com | www.pjzxyl.cn | www.18617.com | www.00772q.com | hggjtg12.com | 2643e.com | 520159407.com | 3066aaa.com | 7811ww.com | 3078p.com | ylg56789.com | 135055.com | www.397760.com | WWW.447392.COM | WWW.817224.COM | WWW.260209.COM | WWW.209250.COM | WWW.84110.COM | www.982pk.com | www.53900k.com | www.226467.com | www.087p.com | www.w84l.com | www.38138e.com | www.8864tt.com | www.799666c.com | 256777a.com | 8827kkk.com | JS1388f.com | i7742.com | yh22999.com | ll40033.com | 5622i.com | 3045522.com | 3983004.com | 7720q.com | ylzz1.cc | 3202y.com | 15n15.net | j3.cc | yl66yl11.com | 8200com | 6396u.com | 15f8.net | 79333.com | hh03.com | 915310.com | 7335o.com | js89w.vip | 874755.com | 3822s.com | x4255.com | 77606w.com | 9170110.com | mohan2013.com | i58955.com | 00774tt.com | 0747nn.com | 4023.com | 18438w.com | www.q456x.com | www.4212z.com | www.xpj5959.com | www.295002.com | www.99552vv.com | www.392229.com | www.68993225.com | www.2221103.com | www.77801g.com | www.6769r.com | www.gczj6.com | WWW.357945.COM | WWW.449988.COM | WWW.65615.COM | WWW.334528.COM | WWW.805836.COM | www.820380.com | www.375805.com | www.33997o.com | 1591eee.com | 6220tt.com | 15856d.com | 99909k.com | 6403p.com | 55899i.com | www.2y926.com | www.00772f.com | www.3w555.com | www.959595.bet | www.26299b.com | WWW.314605.COM | WWW.488152.COM | WWW.260809.COM | WWW.192118.COM | www.394211.com | 6hgp.com | 33678ff.com | 98955v.com | nn500e.com | 20188z.com | www.4727.com | www.zsjzxyy.com | www.78949f.com | WWW.647855.COM | WWW.655755.COM | WWW.153601.COM | www.599280.com | www.2236444.com | s00351.com | 1294i.cc | yf688.org | www.a81m.cc | www.4546600.com | www.86450.com | WWW.416989.COM | WWW.90608.COM | www.877876.com | 44840.com | 61320055.com | 9679y.com | 4023p.com | www.38138p.com | www.dw777.net | WWW.369004.COM | WWW.873466.COM | www.683717.com | 6hcc44.com | 22665144.com | 55545k.com | www.5049j.com | www.52062o.com | www.9478b.com | WWW.656556.COM | WWW.860680.COM | www.666613.com | 444000rrr.com | 294650.com | www.cp0018.com | www.750041.com | www.csgc8.com | WWW.777795.COM | www.388510.com | 55970.net | 3967p.com | 6177004.com | www.805sun.com | www.lqc0.com | WWW.200913.COM | www.293255.com | 0860n.com | r45638.com | www.4058p.com | www.9646m.com | WWW.312036.COM | WWW.216926.COM | 1364.com | 3473w.com | www.hjcp8.com | www.1466h.com | WWW.20958.COM | WWW.62216.COM | 30007a.com | 2222com3.com | www.c44ss.com | www.1199.am | WWW.63408.COM | www.653152.com | 3822u.com | 82997.com | www.3066qq.com | www.3416t.com | WWW.676643.COM | www.52833.com | mm444000.com | www.97cp345.com | www.3790011.com | WWW.450569.COM | www.507381.com | 16340003.com | 61828.biz | www.1764m.com | WWW.97757.COM | www.607263.com | 2978qp.com | zhcp37.com | www.56011k.com | WWW.163102.COM | www.621441.com | 1468yyy.com | le888m.com | www.a2418.com | WWW.181224.COM | www.154688.com | zjgcfc.com | www.7415m.com | www.97jsc.com | www.gczj2.com | WWW.578252.COM | so11.cc | 2544c2.com | www.3566kk.com | WWW.508026.COM | 334466.net | hc333.vip | www.biying940vip.com | www.fcyl3.com | www.862870.com | hc8001.com | 20771166.com | www.50024d.com | WWW.448590.COM | 4809b.com | 0747mm.com | www.7714k.com | WWW.488533.COM | 168cp-h.com | 2709o.com | www.4923w.com | WWW.326448.COM | 723012.com | 2805o.com | www.99677p.com | WWW.810929.COM | 88052.vip | 33313s.com | www.6832i.com | www.843879.com | 85698c.com | www.9737kk.me | WWW.213108.COM | www.196303.com | 3778yy.com | www.w84k.com | WWW.407060.COM | 112j.net | 7744eee.com | www.50052l.com | www.914979.com | tz478.com | www.huangma27.com | WWW.571505.COM | www.84966.com | 9xh.vip | www.35918hh.com | WWW.834967.COM | 267365.com | www.4996ln.com | WWW.202367.COM | icesnow.com.cn | 6220e.com | www.3416t.com | www.449589.com | 800vns.com | www.35898c.com | WWW.253791.COM | 7003l.com | www.4996dt.com | WWW.552060.COM | 2190a.com | www.609024.com | WWW.699059.COM | 7605z.com | ks3337.com | www.c136.vip | 100wk.net | 33115q.com | www.66ffz.com | www.025728.com | 0015hh.com | www.9478s.com | www.420689.com | yy7742.com | www.66652d.com | www.513061.com | 8569844.com | www.66621j.com | www.477680.com | 2490g.com | www.29277d.com | www.312299.com | 99567c.com | www.87467.com | www.332910.com | 44uu8332.com | www.5027.com | www.33588o.com | 2677zzz.com | WWW.771882.COM | 2506q.com | www.tc1158.com | WWW.54566.COM | 11989y.com | www.79095y.com | WWW.642658.COM | 0715563.com | www.3303.com | www.561518.com | 000000oe.cn | www.ya055.com | 66094466.com | www.983888d.com | WWW.419646.COM | cc4675.com | www.4809v.com | www.793990.com | be9458.com | www.qmkl5.com | bc21888.com | www.7415o.com | WWW.78608.COM | 9007893.com | www.97655g.com | www.131763.com | hrviip1.com | WWW.358680.COM | 63964444.com | www.1239999.cc | www.382688.com | w47479.com | WWW.333628.COM | dz825.com | www.97jsc.com | www.493381.com | 35252m.com | WWW.309122.COM | 34p35.com | www.06303.com | www.52072m.com | www.27363x.com | WWW.573692.COM | 4465y.com | www.2632j.com | 9y88.vip | www.9895o.com | www.818807.com | 66876n.com | WWW.261521.COM | 6118z.com | www.66652m.com | 29918l.com | www.4058cc.com | www.934077.com | 500000419.com | WWW.753500.COM | 461653.com | www.33112r.com | hga030.com | www.3032ii.com | www.657832.com | gc722.com | WWW.709024.COM | 3890t.com | www.hf5881.com | 2546b.com | www.858466.com | 123bdz.com | www.sdoroviy.com | www.582993.com | 2998h.com | WWW.386885.COM | wns4.net | WWW.24478.COM | 4488z.com | WWW.866425.COM | ylzz1.cc | www.7782j.com | 6137g.com | www.6939m.com | www.ok0110.com | www.63606u.com | www.235892.com | www.9737rr.com | www.717224.com | www.2945d.com | WWW.625201.COM | 2677vvv.com | WWW.273819.COM | 2jsfff.com | WWW.137144.COM | 8381m.com | WWW.900154.COM | 3482v.com | WWW.920098.COM | ddd3405.com | WWW.524712.COM | 54146655.com | WWW.121751.COM |